Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates.
Molecules
; 21(12)2016 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-27941622
ABSTRACT
Nine new dihydrochloride salts of 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-alkoxyethoxybenzoates were designed and synthesized. The physicochemical properties such as lipophilicity index (log kw) and dissociation constant (pKa) were experimentally determined and compared to the software calculated data. The lipophilicity index was determined by means of reversed-phase high performance liquid chromatography (RP-HPLC). The pKa values were determined by means of capillary zone electrophoresis. The "drug-likeness" properties according to the Lipinski Rule of Five and prediction of possible blood-brain barrier penetration were computed and discussed.
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Base de dados:
MEDLINE
Assunto principal:
Benzoatos
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Software
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Cromatografia Líquida de Alta Pressão
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Cromatografia de Fase Reversa
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Lipídeos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article