Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis.
Blood Purif
; 43(1-3): 101-122, 2017.
Article
em En
| MEDLINE
| ID: mdl-27960188
ABSTRACT
INTRODUCTION:
Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients.METHODS:
We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status.RESULTS:
Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid.CONCLUSIONS:
ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina E
/
Diálise Renal
/
Materiais Revestidos Biocompatíveis
/
Membranas Artificiais
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article