Thymic Function Impacts the Peripheral CD4/CD8 Ratio of HIV-Infected Subjects.
Clin Infect Dis
; 64(2): 152-158, 2017 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-27986677
ABSTRACT
BACKGROUND:
The persistence of an inverted CD4/CD8 ratio has been extensively associated with the increased morbimortality of chronic human immunodeficiency virus (HIV)-infected subjects. Thymic function is crucial for the maintenance of T cell homeostasis. We explored the impact of thymic function on the CD4/CD8 ratio of HIV-infected subjects.METHODS:
In a cohort of 53 antiretroviral-naive HIV-infected subjects, the measure of thymic volume, as a representative marker for thymic function, was available at baseline and at 12, 24, and 48 weeks post antiretroviral treatment.RESULTS:
Baseline thymic volume was associated with the CD4/CD8 ratio ( Ρ = 0.413, P = .002), being this association highly dependent on the CD4 T cell levels. In subjects who achieved undetectable viral load after treatment (n = 33), a higher baseline thymic volume was associated with a higher increase in CD4 T cell counts and a decreasing trend in CD8 T cell counts during follow-up. Moreover, the baseline thymic volume was independently associated with the normalization of the CD4/CD8 ratio after 96 weeks of treatment (odds ratio, 95% confidence interval 1.95 (1.07-3.55); P = .03).CONCLUSIONS:
Our data indicate the relevance of the remaining thymic function before the start of treatment to the CD4/CD8 ratio of HIV- infected subjects and, hence, potentially, in their clinical progression.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Timo
/
Infecções por HIV
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HIV-1
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Relação CD4-CD8
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article