Primary total laryngectomy and pharyngolaryngectomy in T4 pharyngolaryngeal cancers: Oncologic and functional results and prognostic factors.
Eur Ann Otorhinolaryngol Head Neck Dis
; 134(3): 151-154, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-27988198
ABSTRACT
OBJECTIVES:
The aims of this study were to assess oncologic and functional outcome in primary total laryngectomy or pharyngolaryngectomy (TL/TL/TPL) for laryngeal or hypopharyngeal cancer with extra-laryngeal extension (T4) and to determine the predictive factors of these results. MATERIAL ANDMETHODS:
A retrospective analysis was performed on the computerized medical records of all patients undergoing primary TL/TPL for T4 larynx or hypopharynx squamous cell carcinoma between 2000 and 2014 at our institution. Predictive factors of oncologic and functional outcome were investigated on univariate and multivariate analysis.RESULTS:
Sixty-three patients (58 men, 5 women; mean age, 68.8±9.7 years) were included. Overall and disease-specific survivals were 69% and 80% at 3 years, and 56% and 69% at 5 years, respectively. On multivariate analysis, gender (female, P<0.001), ASA score (ASA≥3; P=0.006) and vascular embolism (P=0.006) had significant pejorative impact on overall survival. Six months after end of treatment, 90% of patients had recovered independent oral feeding and 83% of those with tracheoesophageal voice prostheses had recovered an intelligible voice.CONCLUSION:
Primary TL/TPL remains the gold standard treatment for T4 larynx or hypopharynx cancer. It provides satisfactory oncologic and functional outcomes.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Faringectomia
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Carcinoma de Células Escamosas
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Neoplasias Faríngeas
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Neoplasias Laríngeas
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Laringectomia
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article