Lack of ß, ß-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice.

Wu, Lei; Guo, Xin; Hartson, Steven D; Davis, Mary Abby; He, Hui; Medeiros, Denis M; Wang, Weiqun; Clarke, Stephen L; Lucas, Edralin A; Smith, Brenda J; von Lintig, Johannes; Lin, Dingbo

Wu, Lei; Guo, Xin; Hartson, Steven D; Davis, Mary Abby; He, Hui; Medeiros, Denis M; Wang, Weiqun; Clarke, Stephen L; Lucas, Edralin A; Smith, Brenda J; von Lintig, Johannes; Lin, Dingbo.

Afiliação

Wu L; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Guo X; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Hartson SD; Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, USA.
Davis MA; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
He H; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Medeiros DM; Graduate School, University of Missouri-Kansas City, Kansas City, MO, USA.
Wang W; Department of Food, Nutrition, Dietetics, and Health, Kansas State University, Manhattan, KS, USA.
Clarke SL; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Lucas EA; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
Smith BJ; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.
von Lintig J; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Lin D; Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK, USA.

Mol Nutr Food Res ; 61(5)2017 05.

Article em En | MEDLINE | ID: mdl-27991717

Assuntos

Dioxigenases/genética; Mitocôndrias Hepáticas/patologia; Estresse Oxidativo; Animais; Dioxigenases/metabolismo; Fígado/metabolismo; Masculino; Camundongos; Camundongos Knockout; Mitocôndrias Hepáticas/genética; Carbonilação Proteica; Proteoma/genética; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

Liver; Mitochondrial dysfunction; Mitochondrial proteome; Oxidative stress; ß, ß-Carotene-9', 10'-oxygenase 2 (BCO2)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mitocôndrias Hepáticas / Estresse Oxidativo / Dioxigenases Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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