Peroxisome proliferator-activated receptor-ß/Î´ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation.

Yao, Pei-Li; Chen, Liping; Dobrzanski, Tomasz P; Zhu, Bokai; Kang, Boo-Hyon; Müller, Rolf; Gonzalez, Frank J; Peters, Jeffrey M

Yao, Pei-Li; Chen, Liping; Dobrzanski, Tomasz P; Zhu, Bokai; Kang, Boo-Hyon; Müller, Rolf; Gonzalez, Frank J; Peters, Jeffrey M.

Afiliação

Yao PL; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.
Chen L; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.
Dobrzanski TP; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.
Zhu B; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.
Kang BH; Non-clinical Research Institute, Chemon, Jeil-Ri, Yangji-Myeon, Cheoin-Gu, Yongin-Si, Gyeonggi-Do, Korea.
Müller R; Institute of Molecular Biology and Tumor Research, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Gonzalez FJ; Laboratory of Metabolism, National Cancer Institute, Bethesda, Maryland.
Peters JM; Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania.

Mol Carcinog ; 56(5): 1472-1483, 2017 05.

Article em En | MEDLINE | ID: mdl-27996177

Assuntos

Neuroblastoma/patologia; PPAR delta/metabolismo; PPAR beta/metabolismo; Fatores de Transcrição SOXB1/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Animais; Diferenciação Celular/fisiologia; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos; Feminino; Humanos; Camundongos Nus; Neuroblastoma/tratamento farmacológico; Neuroblastoma/metabolismo; PPAR delta/genética; PPAR beta/genética; PTEN Fosfo-Hidrolase/metabolismo; Receptor alfa de Ácido Retinoico/metabolismo; Tretinoína/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

SOX2; neuroblastoma; p53; peroxisome proliferator-activated receptor-ß/Î´; retinoid acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / PPAR beta / PPAR delta / Fatores de Transcrição SOXB1 / Neuroblastoma Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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