A Modular Access to (±)-Tubocurine and (±)-Curine - Formal Total Synthesis of Tubocurarine.
J Org Chem
; 82(2): 1205-1217, 2017 01 20.
Article
em En
| MEDLINE
| ID: mdl-27997804
ABSTRACT
Two consecutive Cu-catalyzed Ullmann-type C-O couplings permitted the first successful entry toward the curare alkaloids (±)-tubocurine and (±)-curine. Starting from vanillin, the synthetic sequence comprises 15 linear steps and includes a total of 24 transformations. In addition, the total synthesis of tubocurine represents a formal total synthesis of the famous arrow poison alkaloid tubocurarine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tubocurarina
/
Química Orgânica
/
Isoquinolinas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article