Optimization and evaluation of Oridonin-loaded Soluplus®-Pluronic P105 mixed micelles for oral administration.
Int J Pharm
; 518(1-2): 193-202, 2017 Feb 25.
Article
em En
| MEDLINE
| ID: mdl-28012993
ABSTRACT
In this study, a new type of mixed micelles was developed using Soluplus® (SOL) and Pluronic® P105 (P105) for the encapsulation of Oridonin (ORN). Oridonin-loaded micelles (ORN-M) were simply prepared using solvent evaporation and characterized for particle size, particle morphology, encapsulation efficiency, and drug loading. In addition, the in vitro drug release behavior of ORN-M was assessed using the widely applied dialysis bag technique. The pharmacokinetic property of ORN was explored in rats after oral administration of ORN-M. Optimized ORN-M were of a small size (137.2±1.65nm) and spherical shape when the ratio of SOLP105 was 31, with entrapment efficiency 90.48±1.85% and drug loading 15.08±0.38%. Oral absorption capacity of ORN was greatly enhanced with a relative bioavailability of 210.55% in comparison to that of in-house suspensions, which suggests that ORN-M shows significantly improved bioavailability and drug absorption characteristics. Overall, the optimized SOL-P105 dual mixed micelles show great potential for use as oral drug carriers for cancer treatment.
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MEDLINE
Assunto principal:
Polietilenoglicóis
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Polivinil
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Portadores de Fármacos
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Poloxâmero
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Diterpenos do Tipo Caurano
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Micelas
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Antineoplásicos Fitogênicos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article