The value of new genome references.
Exp Cell Res
; 358(2): 433-438, 2017 09 15.
Article
em En
| MEDLINE
| ID: mdl-28017728
ABSTRACT
Genomic information has become a ubiquitous and almost essential aspect of biological research. Over the last 10-15 years, the cost of generating sequence data from DNA or RNA samples has dramatically declined and our ability to interpret those data increased just as remarkably. Although it is still possible for biologists to conduct interesting and valuable research on species for which genomic data are not available, the impact of having access to a high quality whole genome reference assembly for a given species is nothing short of transformational. Research on a species for which we have no DNA or RNA sequence data is restricted in fundamental ways. In contrast, even access to an initial draft quality genome (see below for definitions) opens a wide range of opportunities that are simply not available without that reference genome assembly. Although a complete discussion of the impact of genome sequencing and assembly is beyond the scope of this short paper, the goal of this review is to summarize the most common and highest impact contributions that whole genome sequencing and assembly has had on comparative and evolutionary biology.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sequência de Bases
/
Mapeamento Cromossômico
/
Genoma
/
Biologia Computacional
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article