Differentiating regressed melanoma from regressed lichenoid keratosis.
J Cutan Pathol
; 44(4): 338-341, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-28026045
ABSTRACT
BACKGROUND:
Distinguishing regressed lichen planus-like keratosis (LPLK) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients.OBJECTIVE:
We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed LPLK.METHODS:
Twenty actively inflamed LPLK, 12 LPLK with regression and 15 melanomas with regression were compared and evaluated by hematoxylin and eosin staining as well as Melan-A, microphthalmia transcription factor (MiTF) and cytokeratin (AE1/AE3) immunostaining.RESULTS:
(1) A total of 40% of regressed melanomas showed complete or near complete loss of melanocytes within the epidermis with Melan-A and MiTF immunostaining, while 8% of regressed LPLK exhibited this finding. (2) Necrotic keratinocytes were seen in the epidermis in 33% regressed melanomas as opposed to all of the regressed LPLK. (3) A dense infiltrate of melanophages in the papillary dermis was seen in 40% of regressed melanomas, a feature not seen in regressed LPLK.CONCLUSIONS:
In summary, our findings suggest that a complete or near complete loss of melanocytes within the epidermis strongly favors a regressed melanoma over a regressed LPLK. In addition, necrotic epidermal keratinocytes and the presence of a dense band-like distribution of dermal melanophages can be helpful in differentiating these lesions.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Erupções Liquenoides
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Ceratose
/
Melanoma
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article