Tumor suppressor BLU promotes TRAIL-induced apoptosis by downregulating NF-&#954;B signaling in nasopharyngeal carcinoma.

Zhou, Jiahui; Huang, Zunnan; Wang, Ziyou; Liu, Shumin; Grandien, Alf; Ernberg, Ingemar; He, Zhiwei; Zhang, Xiangning

Tumor suppressor BLU promotes TRAIL-induced apoptosis by downregulating NF-κB signaling in nasopharyngeal carcinoma.

Zhou, Jiahui; Huang, Zunnan; Wang, Ziyou; Liu, Shumin; Grandien, Alf; Ernberg, Ingemar; He, Zhiwei; Zhang, Xiangning.

Afiliação

Zhou J; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.
Huang Z; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.
Wang Z; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.
Liu S; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.
Grandien A; Center for Haematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden.
Ernberg I; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
He Z; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.
Zhang X; Department of Pathophysiology and China-America Cancer Research Institute, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong, China.

Oncotarget ; 8(27): 43853-43865, 2017 Jul 04.

Article em En | MEDLINE | ID: mdl-28029652

Assuntos

Apoptose/efeitos dos fármacos; Apoptose/genética; Carcinoma/genética; Carcinoma/metabolismo; NF-kappa B/metabolismo; Neoplasias Nasofaríngeas/genética; Neoplasias Nasofaríngeas/metabolismo; Transdução de Sinais/efeitos dos fármacos; Ligante Indutor de Apoptose Relacionado a TNF/farmacologia; Proteínas Supressoras de Tumor/genética; Animais; Carcinoma/imunologia; Carcinoma/patologia; Caspase 8/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular; Proteínas do Citoesqueleto; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica; Genes Reporter; Humanos; Camundongos; Modelos Biológicos; Carcinoma Nasofaríngeo; Neoplasias Nasofaríngeas/imunologia; Neoplasias Nasofaríngeas/patologia; Poli(ADP-Ribose) Polimerases/metabolismo; Ligação Proteica; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

BLU/ZMYND10; NF-κB; TRAIL; nasopharyngeal carcinoma; tumor suppressor gene

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma / Transdução de Sinais / Neoplasias Nasofaríngeas / NF-kappa B / Apoptose / Proteínas Supressoras de Tumor / Ligante Indutor de Apoptose Relacionado a TNF Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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