Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-ß Peptide.

Hatami, Asa; Monjazeb, Sanaz; Milton, Saskia; Glabe, Charles G

Hatami, Asa; Monjazeb, Sanaz; Milton, Saskia; Glabe, Charles G.

Afiliação

Hatami A; Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697; Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095.
Monjazeb S; Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697.
Milton S; Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697.
Glabe CG; Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, California 92697; Biochemistry Department, Faculty of Science and Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, 23218 Jeddah, Saudi Arabia. Electronic address

J Biol Chem ; 292(8): 3172-3185, 2017 02 24.

Article em En | MEDLINE | ID: mdl-28049728

Assuntos

Doença de Alzheimer/genética; Peptídeos beta-Amiloides/genética; Precursor de Proteína beta-Amiloide/genética; Mutação; Agregados Proteicos; Doença de Alzheimer/patologia; Peptídeos beta-Amiloides/análise; Peptídeos beta-Amiloides/ultraestrutura; Precursor de Proteína beta-Amiloide/análise; Precursor de Proteína beta-Amiloide/ultraestrutura; Humanos; Conformação Proteica

Palavras-chave

Alzheimer disease; aggregation; amyloid-ß (Aß); monoclonal antibody; peptide conformation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos beta-Amiloides / Precursor de Proteína beta-Amiloide / Doença de Alzheimer / Agregados Proteicos / Mutação Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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