Phosphodiesterase 5 inhibition ameliorates angiotensin II-dependent hypertension and renal vascular dysfunction.

Thieme, Manuel; Sivritas, Sema H; Mergia, Evanthia; Potthoff, Sebastian A; Yang, Guang; Hering, Lydia; Grave, Katharina; Hoch, Henning; Rump, Lars C; Stegbauer, Johannes

Thieme, Manuel; Sivritas, Sema H; Mergia, Evanthia; Potthoff, Sebastian A; Yang, Guang; Hering, Lydia; Grave, Katharina; Hoch, Henning; Rump, Lars C; Stegbauer, Johannes.

Afiliação

Thieme M; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Sivritas SH; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Mergia E; Department of Pharmacology and Toxicology, Ruhr-University Bochum, Bochum, Germany.
Potthoff SA; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Yang G; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Hering L; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Grave K; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Hoch H; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Rump LC; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and.
Stegbauer J; Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and johannes.stegbauer@med.uni-duesseldorf.de.

Am J Physiol Renal Physiol ; 312(3): F474-F481, 2017 03 01.

Article em En | MEDLINE | ID: mdl-28052870

Assuntos

Angiotensina II; Anti-Hipertensivos/farmacologia; Pressão Sanguínea/efeitos dos fármacos; Hipertensão/prevenção & controle; Inibidores da Fosfodiesterase 5/farmacologia; Artéria Renal/efeitos dos fármacos; Circulação Renal/efeitos dos fármacos; Citrato de Sildenafila/farmacologia; Vasodilatadores/farmacologia; Animais; GMP Cíclico/metabolismo; Modelos Animais de Doenças; Relação Dose-Resposta a Droga; Hipertensão/induzido quimicamente; Hipertensão/enzimologia; Hipertensão/fisiopatologia; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo III/deficiência; Óxido Nítrico Sintase Tipo III/genética; Artéria Renal/enzimologia; Artéria Renal/fisiopatologia; Vasodilatação/efeitos dos fármacos; Alcaloides de Vinca/farmacologia

Palavras-chave

angiotensin; cGMP; hypertension; phosphodiesterase; renal blood flow

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artéria Renal / Circulação Renal / Vasodilatadores / Pressão Sanguínea / Angiotensina II / Inibidores da Fosfodiesterase 5 / Citrato de Sildenafila / Hipertensão / Anti-Hipertensivos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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