[Effects of water extract of salvia miltiorrhiza aganst renal injury on rats exposed to cadmium].

Objective: To investigate the effects of water extract of salvia miltiorrhiza aganst renal injury on rats exposed to cadmium. Methods: Twenty female Wistar rats were randomly divided into blank control group (8), 32 rats in model group, conventional breeding, the blank control group received intraperitoneal injection of saline 5 ml·kg-1·d-1, model group with 2.8 mg·kg-1·d-1 of cadmium chloride solution by intraperitoneal injection. After the success in modeling, the model group was divided into treatment group (salvia extract high dose 2.7 g·kg-1·d-1, low water extract of salvia a dose of 1.35 g·kg-1·d-1), negative control group, positive control group. After 4 weeks to experiment in the drug group, the water extract of salvia miltiorrhiza by intragastric administration, the positive control group using sodium selenite solution 0.05 mg·kg-1·d-1 gavage, negative control group, the control group was given the same physical volume of saline water gastric 2.7 ml·kg-1·d-1, respectively. Each group intervention for 10 weeks. At the end of the experiment, serum was collected at, were used to detect the serum oxide dismutase (SOD), malondialdehyde (MDA), serum total antioxidant capacity (T-AOC). Results: Danshen aqueous extract can make dye CD rats body weight growth faster, the serum SOD activity decreased significantly[(241.0±2.8) U/ml vs(219.6±4.6) U/ml, P<0.05], serum MDA increased greatly[(7.2±0.3) µmol/L vs(11.9±0.9) µmol/L, P<0.01], to enhance the serum total antioxidant capacity[(8.7±1.5) U/ml vs(4.6±2.0)U/ml, P<0.05]. Conclusion: Danshen aqueous extract has obvious antioxidant injury, in reducing swelling of renal tubular epithelial cells, improve renal function effect significantly.