[Analysis for protection rate and antibody levels of epidemic cerebrospinal meningitis among children aged between 3-23 months in Liuzhou, in 2012].
Zhonghua Yu Fang Yi Xue Za Zhi
; 50(12): 1079-1083, 2016 Dec 06.
Article
em Zh
| MEDLINE
| ID: mdl-28057112
ABSTRACT
Objective:
To understand the level of bactericidal antibodies against Neisseria meningitidis and their rate of protection in children aged between 3 and 23 months, in Liuzhou, in 2012.Methods:
Convenience sampling was performed in Liujiang, Rong'an and Sanjiang Counties from May through August, 2012. The inclusion criteria for 603 subjects were Children aged between 3 and 23 months; no history of meningococcal meningitis; no vaccination against Neisseria meningitidis serogroup C; more than 30 days from the last vaccination against Neisseria meningitidis serogroup A. Demographic information and immunization history of the subjects were obtained using questionnaires. Venous blood samples (2.0 ml each) were collected and levels of Neisseria meningitides antibodies determined using a Serum Bactericidal Assay (SBA). The geometric mean titer (GMT) of serum bacterial antibodies was positive when it was greater than or equal to 1â¶2 and protective when greater than 1â¶8. Chi-square and Fisher's exact tests were used to compare differences in the positive and protective rates of serum antibodies of Neisseria meningitidis serogroup A and Neisseria meningitidis serogroup C, among children with different demographic characteristics. Kruskal-Wallis H test was used to compare differences in the GMT of serum antibodies of Neisseria meningitidis serogroup A and Neisseria meningitidis serogroup C, among children with different demographic characteristics.Results:
Of 603 subjects, 325 (53.9%) were female and 278 (46.1%) were male; 276 (45.8%), 143 (23.7%) and 184 (30.5%) subjects were administered, respectively, no treatment, 1 dose vaccine and 2 doses vaccine. The GMT of serum antibodies against group A Neisseria meningitidis was 1â¶1.11, the positive rate was 7.6% (46) and the protective rate was 2.0% (12). The GMT of antibodies in children receiving 1 vaccine dose was 1â¶1.16 and the protective rate was 3.5% (5), both values higher than those in children receiving 2 vaccine doses (GMT 1â¶1.2, protective rate 3.5% (5)). However, these differences were not statistically significant (GMT H=0.64, P=0.728; protective rate Fisher's exact test, P= 0.080). The GMT of antibodies in children receiving 1 and 2 doses of meningococcal polysaccharide vaccines were 1â¶1.12 and 1â¶2.30, respectively (≤180 d). The GMT of serum antibodies for group C meningococcal vaccine was 1â¶1.18 and its positive and protective rates were 14.6% (88) and 2.2% (13), respectively.Conclusion:
Children aged between 3 and 23 months are susceptible to Neisseria meningitidis groups A and C. The immune effectiveness of group A meningococcal polysaccharide vaccine is relatively poor in this age group and their antibody levels decreased rapidly.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neisseria meningitidis Sorogrupo A
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Neisseria meningitidis Sorogrupo C
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Anticorpos Antibacterianos
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Neisseria meningitidis
Idioma:
Zh
Ano de publicação:
2016
Tipo de documento:
Article