Sumoylation in Lens Differentiation and Pathogenesis.

Xiang, J-W; Chen, Z-G; Gong, L; Xiao, Y; Qing, W-J; Wang, L; Hu, X-H; Huang, Z-X; Qi, R-L; Yang, T-H; Arrigo, A-P; Zhang, L; Tang, X-C; Huang, S; Liu, F-Y; Luo, Z-W; Liu, Y-F; Sun, Q; Gigantelli, J; Liu, Y-Z; Li, D W-C

Xiang, J-W; Chen, Z-G; Gong, L; Xiao, Y; Qing, W-J; Wang, L; Hu, X-H; Huang, Z-X; Qi, R-L; Yang, T-H; Arrigo, A-P; Zhang, L; Tang, X-C; Huang, S; Liu, F-Y; Luo, Z-W; Liu, Y-F; Sun, Q; Gigantelli, J; Liu, Y-Z; Li, D W-C.

Afiliação

Li DW; Key Laboratory of Protein Chemistry and Developmental Biology of Educational Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081,. China.

Curr Mol Med ; 16(10): 859-870, 2017.

Article em En | MEDLINE | ID: mdl-28067169

ABSTRACT

ABSTRACT

Sumoylation, a post-translational modification discovered over a decade ago, turns out to be a very important regulatory mechanism mediating multiple cellular processes. Recent studies from our laboratory and others also revealed that it plays a crucial role in regulating both differentiation and pathogenesis of the ocular lens. This review will summarize these progresses.

Assuntos

Catarata/genética; Diferenciação Celular/genética; Processamento de Proteína Pós-Traducional/genética; Sumoilação/genética; Catarata/fisiopatologia; Humanos; Cristalino/patologia

Palavras-chave

Lens; cataractogenesis; differentiation; pathogenesis; sumoylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Catarata / Diferenciação Celular / Processamento de Proteína Pós-Traducional / Sumoilação Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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