H19 non-coding RNA in urine cells detects urothelial carcinoma: a pilot study.
Biomarkers
; 22(7): 661-666, 2017 Nov.
Article
em En
| MEDLINE
| ID: mdl-28067543
ABSTRACT
CONTEXT Urothelial carcinoma (UC) is common and highly recurrent. Diagnosis and follow-up involve invasive cystoscopies. OBJECTIVE:
To evaluate H19 RNA in urine cells as diagnostic tool for UC. MATERIALS ANDMETHODS:
RT-PCR analysis of urine samples from healthy volunteers and UC patients.RESULTS:
H19 RNA was unequivocally detected in the urine of 90.5% of patients and 25.9% of controls. H19 copies were three orders of magnitude higher in patients. Receiver operating characteristic analysis showed an area under the curve of 0.933.CONCLUSIONS:
This pilot study shows that urinary cell H19 is a highly sensitive test for UC and pending verification could transform patient management.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Urológicas
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Urotélio
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RNA Longo não Codificante
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article