Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes.

Chandel, Nirupama; Ayasolla, Kamesh; Wen, Hongxiu; Lan, Xiqian; Haque, Shabirul; Saleem, Moin A; Malhotra, Ashwani; Singhal, Pravin C

Chandel, Nirupama; Ayasolla, Kamesh; Wen, Hongxiu; Lan, Xiqian; Haque, Shabirul; Saleem, Moin A; Malhotra, Ashwani; Singhal, Pravin C.

Afiliação

Chandel N; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Ayasolla K; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Wen H; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Lan X; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Haque S; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Saleem MA; Renal Academic Unit, University of Bristol, UK.
Malhotra A; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA.
Singhal PC; Department of Medicine, Hofstra Northwell Health Medical School and Feinstein Institute for Medical Research, New York, USA. Electronic address: psinghal@nshs.edu.

Exp Mol Pathol ; 102(1): 97-105, 2017 02.

Article em En | MEDLINE | ID: mdl-28069388

Assuntos

Podócitos/metabolismo; Receptores de Calcitriol/genética; Sistema Renina-Angiotensina/genética; Sirtuína 1/genética; Acetilação; Angiotensinogênio/genética; Angiotensinogênio/metabolismo; Animais; Western Blotting; Células Cultivadas; Humanos; Rim/citologia; Rim/metabolismo; Lisina/genética; Lisina/metabolismo; Camundongos Knockout; Modelos Genéticos; Podócitos/citologia; Interferência de RNA; Receptor Tipo 1 de Angiotensina/genética; Receptor Tipo 1 de Angiotensina/metabolismo; Receptores de Calcitriol/deficiência; Renina/genética; Renina/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Sirtuína 1/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema Renina-Angiotensina / Receptores de Calcitriol / Podócitos / Sirtuína 1 Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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