Extinction and recovery of an avoidance memory impaired by scopolamine.
Physiol Behav
; 171: 192-198, 2017 03 15.
Article
em En
| MEDLINE
| ID: mdl-28069463
ABSTRACT
Pre-training administration of scopolamine (SCP) resembles situations of cholinergic dysfunction, leading to memory impairment of mice trained in an inhibitory avoidance task. We suggest here that SCP does not impair memory formation, but acquisition is affected in a way that reduces the strength of the stored memory, thus making this memory less able to control behavior when tested. Hence, a memory trace is stored, but is poorly expressed during the test. Although weakly expressed, this memory shows extinction during successive tests, and can be strengthened by using a reminder. Our results indicate that memories stored under cholinergic dysfunction conditions seem absent or lost, but are in fact present and experience common memory processes, such as extinction, and could be even recovered by using appropriate protocols.
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Base de dados:
MEDLINE
Assunto principal:
Escopolamina
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Aprendizagem da Esquiva
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Antagonistas Colinérgicos
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Extinção Psicológica
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Transtornos da Memória
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article