Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses.
Cell Rep
; 18(2): 324-333, 2017 01 10.
Article
em En
| MEDLINE
| ID: mdl-28076778
ZIKA virus (ZIKV) is an emerging pathogen responsible for neurological disorders and congenital microcephaly. However, the molecular basis for ZIKV neurotropism remains poorly understood. Here, we show that Axl is expressed in human microglia and astrocytes in the developing brain and that it mediates ZIKV infection of glial cells. Axl-mediated ZIKV entry requires the Axl ligand Gas6, which bridges ZIKV particles to glial cells. Following binding, ZIKV is internalized through clathrin-mediated endocytosis and traffics to Rab5+ endosomes to establish productive infection. During entry, the ZIKV/Gas6 complex activates Axl kinase activity, which downmodulates interferon signaling and facilitates infection. ZIKV infection of human glial cells is inhibited by MYD1, an engineered Axl decoy receptor, and by the Axl kinase inhibitor R428. Our results highlight the dual role of Axl during ZIKV infection of glial cells: promoting viral entry and modulating innate immune responses. Therefore, inhibiting Axl function may represent a potential target for future antiviral therapies.
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Base de dados:
MEDLINE
Assunto principal:
Neuroglia
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Proteínas Proto-Oncogênicas
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Receptores Proteína Tirosina Quinases
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Internalização do Vírus
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Zika virus
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Imunidade Inata
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article