Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome.
Curr Eye Res
; 42(6): 876-879, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28085507
ABSTRACT
PURPOSE:
To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.METHOD:
Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.RESULTS:
The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014).CONCLUSION:
Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Síndrome de Exfoliação
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Estresse Oxidativo
/
Dissulfetos
/
Homeostase
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article