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Conjugation site analysis of antibody-drug-conjugates (ADCs) by signature ion fingerprinting and normalized area quantitation approach using nano-liquid chromatography coupled to high resolution mass spectrometry.
Sang, Hua; Lu, Gaoyuan; Liu, Yazhong; Hu, Qiyue; Xing, Weifeng; Cui, Dongbing; Zhou, Fang; Zhang, Jingwei; Hao, Haiping; Wang, Guangji; Ye, Hui.
Afiliação
  • Sang H; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Lu G; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Liu Y; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Hu Q; Shanghai Hengrui Pharmaceutical Co., Ltd, Shanghai, 200245, China.
  • Xing W; Shanghai Hengrui Pharmaceutical Co., Ltd, Shanghai, 200245, China.
  • Cui D; Shanghai Hengrui Pharmaceutical Co., Ltd, Shanghai, 200245, China.
  • Zhou F; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Zhang J; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Hao H; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
  • Wang G; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: Guangjiwang@hotmail.com.
  • Ye H; Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: cpuyehui@cpu.edu.cn.
Anal Chim Acta ; 955: 67-78, 2017 Feb 22.
Article em En | MEDLINE | ID: mdl-28088282
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Trastuzumab / Maitansina Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imunoconjugados / Trastuzumab / Maitansina Idioma: En Ano de publicação: 2017 Tipo de documento: Article