Iron overload and altered iron metabolism in ovarian cancer.
Biol Chem
; 398(9): 995-1007, 2017 08 28.
Article
em En
| MEDLINE
| ID: mdl-28095368
ABSTRACT
Iron is an essential element required for many processes within the cell. Dysregulation in iron homeostasis due to iron overload is detrimental. This nutrient is postulated to contribute to the initiation of cancer; however, the mechanisms by which this occurs remain unclear. Defining how iron promotes the development of ovarian cancers from precursor lesions is essential for developing novel therapeutic strategies. In this review, we discuss (1) how iron overload conditions may initiate ovarian cancer development, (2) dysregulated iron metabolism in cancers, (3) the interplay between bacteria, iron, and cancer, and (4) chemotherapeutic strategies targeting iron metabolism in cancer patients.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Sobrecarga de Ferro
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Ferro
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article