AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents.
Angew Chem Int Ed Engl
; 56(8): 2118-2122, 2017 02 13.
Article
em En
| MEDLINE
| ID: mdl-28097756
ABSTRACT
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by inâ
vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
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MEDLINE
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En
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2017
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Article