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AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents.
Nagy, Gábor; Szikra, Dezso; Trencsényi, György; Fekete, Anikó; Garai, Ildikó; Giani, Arianna M; Negri, Roberto; Masciocchi, Norberto; Maiocchi, Alessandro; Uggeri, Fulvio; Tóth, Imre; Aime, Silvio; Giovenzana, Giovanni B; Baranyai, Zsolt.
Afiliação
  • Nagy G; Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.
  • Szikra D; University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Trencsényi G; Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.
  • Fekete A; University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Garai I; Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.
  • Giani AM; University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Negri R; University of Debrecen, Medical Imaging Clinic, Nagyerdei krt. 98, 4032, Debrecen, Hungary.
  • Masciocchi N; Scanomed Ltd., Nagyerdei Krt. 98, 4032, Debrecen, Hungary.
  • Maiocchi A; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100, Novara, Italy.
  • Uggeri F; Dipartimento di Scienze del Farmaco, Università del Piemonte Orientale, Largo Donegani 2/3, 28100, Novara, Italy.
  • Tóth I; Dipartimento di Scienza e Alta Tecnologia and To.Sca.Lab, Università degli Studi dell'Insubria, via Valleggio 11, 22100, Como, Italy.
  • Aime S; Bracco Imaging spa, Bracco Research Centre, Via Ribes 5, 10010, Colleretto Giacosa (TO), Italy.
  • Giovenzana GB; Bracco Imaging spa, Bracco Research Centre, Via Ribes 5, 10010, Colleretto Giacosa (TO), Italy.
  • Baranyai Z; Department of Inorganic and Analytical Chemistry, University of Debrecen, 4032, Debrecen, Egyetem tér 1, Hungary.
Angew Chem Int Ed Engl ; 56(8): 2118-2122, 2017 02 13.
Article em En | MEDLINE | ID: mdl-28097756
ABSTRACT
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article