Enhanced transient receptor potential channel-mediated Ca<sup>2+</sup> influx in the cells with phospholipase C-Î´1 overexpression: its possible role in coronary artery spasm.

Murakami, Kazuo; Osanai, Tomohiro; Tanaka, Makoto; Nishizaki, Kimitaka; Kinjo, Takahiko; Tanno, Tomohiro; Ishida, Yuji; Suzuki, Akiko; Endo, Tomohide; Tomita, Hirofumi; Okumura, Ken

Enhanced transient receptor potential channel-mediated Ca²⁺ influx in the cells with phospholipase C-Î´1 overexpression: its possible role in coronary artery spasm.

Murakami, Kazuo; Osanai, Tomohiro; Tanaka, Makoto; Nishizaki, Kimitaka; Kinjo, Takahiko; Tanno, Tomohiro; Ishida, Yuji; Suzuki, Akiko; Endo, Tomohide; Tomita, Hirofumi; Okumura, Ken.

Afiliação

Murakami K; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Osanai T; Department of Nursing, Hirosaki University Graduate School of Health Science, 66-1 Hon-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Tanaka M; Department of Hypertension and Stroke Internal Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Nishizaki K; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Kinjo T; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Tanno T; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Ishida Y; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Suzuki A; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Endo T; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Tomita H; Department of Cardiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho Hirosaki, Hirosaki, Aomori Prefecture, Japan.
Okumura K; Division of Cardiology, Saiseikai Kumamoto Hospital, 5-3-1 Chikami Minamiku Kumamoto, Kumamoto, Kumamoto Prefecture, Japan.

Fundam Clin Pharmacol ; 31(4): 383-391, 2017 Aug.

Article em En | MEDLINE | ID: mdl-28107550

Assuntos

Cálcio/metabolismo; Vasoespasmo Coronário/enzimologia; Vasos Coronários/enzimologia; Regulação Enzimológica da Expressão Gênica; Fosfolipase C delta/biossíntese; Canal de Cátion TRPC6/metabolismo; Bloqueadores dos Canais de Cálcio/farmacologia; Vasoespasmo Coronário/genética; Vasos Coronários/efeitos dos fármacos; Células HEK293; Humanos; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/enzimologia; Fosfolipase C delta/genética; Canal de Cátion TRPC6/antagonistas & inibidores

Palavras-chave

Intracellular Ca2+ concentration; PLC-Î´1; coronary spasm; transient receptor potential channel 6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Enzimológica da Expressão Gênica / Cálcio / Vasoespasmo Coronário / Vasos Coronários / Fosfolipase C delta / Canal de Cátion TRPC6 Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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