Development and progression of immobilization-induced skin fibrosis through overexpression of transforming growth factor-ß1 and hypoxic conditions in a rat knee joint contracture model.

Goto, Kyo; Sakamoto, Junya; Nakano, Jiro; Kataoka, Hideki; Honda, Yuichiro; Sasabe, Ryo; Origuchi, Tomoki; Okita, Minoru

Goto, Kyo; Sakamoto, Junya; Nakano, Jiro; Kataoka, Hideki; Honda, Yuichiro; Sasabe, Ryo; Origuchi, Tomoki; Okita, Minoru.

Afiliação

Goto K; a Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Sakamoto J; b Department of Rehabilitation , Nagasaki Memorial Hospital , Nagasaki , Japan.
Nakano J; c Department of Physical Therapy Science, Unit of Physical and Occupational Therapy Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Kataoka H; c Department of Physical Therapy Science, Unit of Physical and Occupational Therapy Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Honda Y; a Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Sasabe R; b Department of Rehabilitation , Nagasaki Memorial Hospital , Nagasaki , Japan.
Origuchi T; a Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences , Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
Okita M; d Department of Rehabilitation , Nagasaki University Hospital , Nagasaki , Japan.

Connect Tissue Res ; 58(6): 586-596, 2017 Nov.

Article em En | MEDLINE | ID: mdl-28121187

Assuntos

Contratura/metabolismo; Fibrose/patologia; Articulação do Joelho/metabolismo; Miofibroblastos/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Animais; Diferenciação Celular/fisiologia; Colágeno Tipo III/metabolismo; Fibroblastos/metabolismo; Hipóxia/metabolismo; Hipóxia/patologia; Articulação do Joelho/patologia; Masculino; Ratos Wistar

Palavras-chave

Hypoxia; collagen; immobilization; myofibroblast; skin fibrosis; transforming growth factor-ß1

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrose / Contratura / Fator de Crescimento Transformador beta1 / Miofibroblastos / Articulação do Joelho Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google