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Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice.
Wang, Zhi-Bin; Han, Ping; Tong, Ling-Chang; Luo, Yi; Su, Wei-Heng; Wei, Xin; Yu, Xu-Hong; Liu, Wei-Ye; Zhang, Xiu-Hua; Lei, Hong; Li, Zhen-Zhen; Wang, Fang; Chen, Jian-Guo; Ma, Tong-Hui; Su, Ding-Feng; Li, Ling.
Afiliação
  • Wang ZB; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Han P; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Tong LC; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Luo Y; Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Su WH; Basal medical College, Dalian Medical University, Dalian, Liaoning 130041, China.
  • Wei X; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Yu XH; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Liu WY; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Zhang XH; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Lei H; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Li ZZ; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Wang F; Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Chen JG; Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
  • Ma TH; Basal medical College, Dalian Medical University, Dalian, Liaoning 130041, China.
  • Su DF; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
  • Li L; Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Sci Rep ; 7: 40986, 2017 01 27.
Article em En | MEDLINE | ID: mdl-28128226
ABSTRACT
Susceptibility to motion sickness (MS) varies considerably among humans. However, the cause of such variation is unclear. Here, we used a classical genetic approach to obtain mouse strains highly sensitive and resistant to MS (SMS and RMS). Proteomics analysis revealed substantially lower swiprosin-1 expression in SMS mouse brains. Inducing MS via rotary stimulation decreased swiprosin-1 in the mouse brains. Swiprosin-1 knockout mice were much more sensitive to motion disturbance. Immunohistochemistry revealed strong swiprosin-1 expression in the vestibular nuclei (VN). Over-expressing swiprosin-1 in the VN of SMS mice decreased MS susceptibility. Down-regulating swiprosin-1 in the VN of RMS mice by RNAi increased MS susceptibility. Additional in vivo experiments revealed decreased swiprosin-1 expression by glutamate via the NMDA receptor. Glutamate increased neuronal excitability in SMS or swiprosin-1 knockout mice more prominently than in RMS or wild-type mice. These results indicate that swiprosin-1 in the VN is a critical determinant of the susceptibility to MS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Núcleos Vestibulares / Enjoo devido ao Movimento Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Núcleos Vestibulares / Enjoo devido ao Movimento Idioma: En Ano de publicação: 2017 Tipo de documento: Article