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Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents.
Carbajales, Carlos; Sawada, Jun-Ichi; Marzaro, Giovanni; Sotelo, Eddy; Escalante, Luz; Sánchez-Díaz Marta, Antonio; García-Mera, Xerardo; Asai, Akira; Coelho, Alberto.
Afiliação
  • Carbajales C; Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
  • Sawada JI; Graduate School of Pharmaceutical Sciences, University of Shizuoka , Suruga-ku, Shizuoka 422-8526, Japan.
  • Marzaro G; Department of Pharmaceutical and Pharmacological Sciences, University of Padova , Via Marzolo 5, 35131 Padova, Italy.
  • Sotelo E; Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
  • Escalante L; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Avenida das Ciencias, s/n, Campus sur, Santiago de Compostela 15782, Spain.
  • Sánchez-Díaz Marta A; Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
  • García-Mera X; Center for Research in Biological Chemistry and Molecular Materials, University of Santiago de Compostela , Jenaro de la Fuente s/n, Campus Vida, Santiago de Compostela 15782, Spain.
  • Asai A; Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela , Avenida das Ciencias, s/n, Campus sur, Santiago de Compostela 15782, Spain.
  • Coelho A; Graduate School of Pharmaceutical Sciences, University of Shizuoka , Suruga-ku, Shizuoka 422-8526, Japan.
ACS Comb Sci ; 19(3): 153-160, 2017 03 13.
Article em En | MEDLINE | ID: mdl-28135059
ABSTRACT
The potent kinesin spindle protein inhibitor CPUYJ039 and a set of analogues were prepared by a target-oriented approach based on a Ugi reaction that uses 2-nitrophenyl isocyanides as key building blocks. The herein documented strategy provides straightforward and atom economical access to potent benzimidazole-based antimitotic agents by exploring the versatility and exploratory power of the Ugi reaction. The results of docking studies and biological activity evaluations of the benzimidazole compounds are also reported.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Cinesinas / Antimitóticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzimidazóis / Cinesinas / Antimitóticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article