Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; Waagepetersen, Helle S; Wollheim, Claes B; Maechler, Pierre

Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; Waagepetersen, Helle S; Wollheim, Claes B; Maechler, Pierre.

Afiliação

Pournourmohammadi S; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland.
Grimaldi M; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland.
Stridh MH; Department of Drug Design and Pharmacotherapy, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark.
Lavallard V; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospital, Geneva, Switzerland.
Waagepetersen HS; Department of Drug Design and Pharmacotherapy, Faculty of Health and Medical Sciences, University of Copenhagen, 2 Universitetsparken, 2100 Copenhagen, Denmark.
Wollheim CB; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland.
Maechler P; Department of Cell Physiology and Metabolism, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland; Faculty Diabetes Center, University of Geneva Medical Center, 1 rue Michel-Servet, 1206 Geneva, Switzerland. Electronic address: Pierre.Maechler@unige.ch.

Int J Biochem Cell Biol ; 88: 220-225, 2017 07.

Article em En | MEDLINE | ID: mdl-28137482

Assuntos

Proteínas Quinases Ativadas por AMP/metabolismo; Catequina/análogos & derivados; Inibidores Enzimáticos/farmacologia; Glutamato Desidrogenase/antagonistas & inibidores; Células Secretoras de Insulina/efeitos dos fármacos; Músculos/efeitos dos fármacos; Estado Pré-Diabético/tratamento farmacológico; Animais; Transporte Biológico/efeitos dos fármacos; Cálcio/metabolismo; Catequina/farmacologia; Catequina/uso terapêutico; Linhagem Celular; Ativação Enzimática/efeitos dos fármacos; Inibidores Enzimáticos/uso terapêutico; Glucose/metabolismo; Glutamato Desidrogenase/metabolismo; Humanos; Insulina/metabolismo; Secreção de Insulina; Células Secretoras de Insulina/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Fibras Musculares Esqueléticas/efeitos dos fármacos; Fibras Musculares Esqueléticas/metabolismo; Músculos/metabolismo; Músculos/patologia; Estado Pré-Diabético/metabolismo; Estado Pré-Diabético/patologia

Palavras-chave

AMPK; Beta-cell; EGCG; Glutamate dehydrogenase; Green tea; Insulin secretion; Muscle cells; Pancreatic islet

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Catequina / Inibidores Enzimáticos / Células Secretoras de Insulina / Proteínas Quinases Ativadas por AMP / Glutamato Desidrogenase / Músculos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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