The epigenetically-regulated miR-34a targeting c-SRC suppresses RAF/MEK/ERK signaling pathway in K-562 cells.
Leuk Res
; 55: 91-96, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28157629
ABSTRACT
Previous reports show that miR-34a suppressed K-562 cell proliferation and contributed to megakaryocytic differentiation of K-562 cells. Here, we reported that miR-34a, a tumor suppressor gene, is down-regulated in the K-562 cells and chronic myeloid leukemia (CML) patients due to aberrant DNA hypermethylation. c-SRC is a target of miR-34a. Restoring miR-34a expression resulted in down-regulation of c-SRC and phosphorylated (Tyr416) c-SRC protein in K-562 cells, which consequently triggered suppression of the RAF/MEK/ERK signaling pathway to decrease cell proliferation.
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Base de dados:
MEDLINE
Assunto principal:
Quinases da Família src
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Sistema de Sinalização das MAP Quinases
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MicroRNAs
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Epigênese Genética
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Quinases raf
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article