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Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels.
Singh, Arjun; Kumar, B Sathish; Alam, Sarfaraz; Iqbal, Hina; Shafiq, Mohammad; Khan, Feroz; Negi, Arvind S; Hanif, Kashif; Chanda, Debabrata.
Afiliação
  • Singh A; Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Kumar BS; Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Alam S; Molecular and Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Iqbal H; Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Shafiq M; Division of Pharmacology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Khan F; Molecular and Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Negi AS; Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
  • Hanif K; Division of Pharmacology, CSIR-Central Drug Research Institute, B.S. 10/1, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India.
  • Chanda D; Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. Electronic address: d.chanda@cimap.res.in.
Eur J Pharmacol ; 799: 84-93, 2017 Mar 15.
Article em En | MEDLINE | ID: mdl-28159537
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Canais de Cálcio / Lignanas / GMP Cíclico / Espaço Intracelular / Anti-Hipertensivos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Bloqueadores dos Canais de Cálcio / Canais de Cálcio / Lignanas / GMP Cíclico / Espaço Intracelular / Anti-Hipertensivos Idioma: En Ano de publicação: 2017 Tipo de documento: Article