Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment.
Int J Rheum Dis
; 21(10): 1809-1814, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-28160411
ABSTRACT
AIM:
To clarify the relationship between active synovitis/osteitis and subsequent residual synovitis (R-synovitis) in patients with rheumatoid arthritis (RA).METHODS:
Three hundred and twenty finger joints of 16 patients with active RA at baseline (Disease Activity Score with 28 joints - erythrocyte sedimentation rate > 3.2) who subsequently achieved clinical low disease activity or remission afterwards were analyzed. Synovial vascularity (SV) was assessed according to a semi-quantitative ultrasound score (grades 0-3). Active synovitis was defined by SV positivity at baseline. R-synovitis was defined by the presence of grade > 2 SV at the 24th week. Osteitis was detected by magnetic resonance imaging (MRI) at baseline as trabecular bone lesions with water content and indistinct margins.RESULTS:
Ultrasonography detected active synovitis in 116 joints at baseline. Forty-seven joints had R-synovitis at the 24th week. MRI detected osteitis in 12 joints at baseline. The presence of active synovitis with osteitis at baseline was significantly correlated with R-synovitis at the 24th week.CONCLUSIONS:
Active synovitis in the presence of osteitis predicted R-synovitis regardless of whether there was a clinical improvement in RA.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Osteíte
/
Artrite Reumatoide
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Sinovite
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Antirreumáticos
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Articulações dos Dedos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article