Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.

Zhao, Di; Lu, Xin; Wang, Guocan; Lan, Zhengdao; Liao, Wenting; Li, Jun; Liang, Xin; Chen, Jasper Robin; Shah, Sagar; Shang, Xiaoying; Tang, Ming; Deng, Pingna; Dey, Prasenjit; Chakravarti, Deepavali; Chen, Peiwen; Spring, Denise J; Navone, Nora M; Troncoso, Patricia; Zhang, Jianhua; Wang, Y Alan; DePinho, Ronald A

Zhao, Di; Lu, Xin; Wang, Guocan; Lan, Zhengdao; Liao, Wenting; Li, Jun; Liang, Xin; Chen, Jasper Robin; Shah, Sagar; Shang, Xiaoying; Tang, Ming; Deng, Pingna; Dey, Prasenjit; Chakravarti, Deepavali; Chen, Peiwen; Spring, Denise J; Navone, Nora M; Troncoso, Patricia; Zhang, Jianhua; Wang, Y Alan; DePinho, Ronald A.

Afiliação

Zhao D; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Lu X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wang G; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Lan Z; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Liao W; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Li J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Liang X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Chen JR; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shah S; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shang X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Tang M; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Deng P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Dey P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Chakravarti D; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Chen P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Spring DJ; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Navone NM; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Troncoso P; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Zhang J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Wang YA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
DePinho RA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

Nature ; 542(7642): 484-488, 2017 02 23.

Article em En | MEDLINE | ID: mdl-28166537

Assuntos

Montagem e Desmontagem da Cromatina; DNA Helicases/metabolismo; Proteínas de Ligação a DNA/metabolismo; Genes Essenciais/genética; Neoplasias/metabolismo; Neoplasias/patologia; PTEN Fosfo-Hidrolase/deficiência; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Montagem e Desmontagem da Cromatina/genética; DNA Helicases/química; DNA Helicases/deficiência; DNA Helicases/genética; Proteínas de Ligação a DNA/química; Proteínas de Ligação a DNA/deficiência; Proteínas de Ligação a DNA/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Glicogênio Sintase Quinase 3 beta/metabolismo; Histonas/metabolismo; Humanos; Lisina/metabolismo; Masculino; Metilação; Terapia de Alvo Molecular; NF-kappa B/metabolismo; Neoplasias/genética; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; Fosforilação; Neoplasias da Próstata/genética; Neoplasias da Próstata/metabolismo; Neoplasias da Próstata/patologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Estabilidade Proteica; Proteólise; Fator de Necrose Tumoral alfa/metabolismo; Ubiquitinação; Proteínas Contendo Repetições de beta-Transducina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA Helicases / Genes Essenciais / Montagem e Desmontagem da Cromatina / Proteínas de Ligação a DNA / PTEN Fosfo-Hidrolase / Neoplasias Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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