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Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450.
Takahashi, Ryan H; Halladay, Jason S; Siu, Michael; Chen, Yuan; Hop, Cornelis E C A; Khojasteh, S Cyrus; Ma, Shuguang.
Afiliação
  • Takahashi RH; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California takahashi.ryan@gene.com.
  • Halladay JS; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
  • Siu M; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
  • Chen Y; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
  • Hop CE; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
  • Khojasteh SC; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
  • Ma S; Departments of Drug Metabolism and Pharmacokinetics (R.H.T., J.S.H., Y.C., C.E.C.A.H., S.C.K., S.M.), and Discovery Chemistry (M.S.), Genentech, Inc., 1 DNA Way, South San Francisco, California.
Drug Metab Dispos ; 45(5): 430-440, 2017 05.
Article em En | MEDLINE | ID: mdl-28188299
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Tiocianatos / Sistema Enzimático do Citocromo P-450 / Compostos Heterocíclicos com 3 Anéis / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Tiocianatos / Sistema Enzimático do Citocromo P-450 / Compostos Heterocíclicos com 3 Anéis / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article