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In Vivo Gold Complex Catalysis within Live Mice.
Tsubokura, Kazuki; Vong, Kenward K H; Pradipta, Ambara R; Ogura, Akihiro; Urano, Sayaka; Tahara, Tsuyoshi; Nozaki, Satoshi; Onoe, Hirotaka; Nakao, Yoichi; Sibgatullina, Regina; Kurbangalieva, Almira; Watanabe, Yasuyoshi; Tanaka, Katsunori.
Afiliação
  • Tsubokura K; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Vong KK; Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
  • Pradipta AR; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Ogura A; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Urano S; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Tahara T; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
  • Nozaki S; RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
  • Onoe H; RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
  • Nakao Y; RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
  • Sibgatullina R; Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan.
  • Kurbangalieva A; Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Street, Kazan, 420008, Russia.
  • Watanabe Y; Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Street, Kazan, 420008, Russia.
  • Tanaka K; RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo, 650-0047, Japan.
Angew Chem Int Ed Engl ; 56(13): 3579-3584, 2017 03 20.
Article em En | MEDLINE | ID: mdl-28198119
ABSTRACT
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albumina Sérica / Complexos de Coordenação / Corantes Fluorescentes / Ouro Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Albumina Sérica / Complexos de Coordenação / Corantes Fluorescentes / Ouro Idioma: En Ano de publicação: 2017 Tipo de documento: Article