The Secrets of Acinetobacter Secretion.
Trends Microbiol
; 25(7): 532-545, 2017 07.
Article
em En
| MEDLINE
| ID: mdl-28216293
ABSTRACT
Infections caused by the bacterial pathogen Acinetobacter baumannii are a mounting concern for healthcare practitioners as widespread antibiotic resistance continues to limit therapeutic treatment options. The biological processes used by A. baumannii to cause disease are not well defined, but recent research has indicated that secreted proteins may play a major role. A variety of mechanisms have now been shown to contribute to protein secretion by A. baumannii and other pathogenic species of Acinetobacter, including a type II secretion system (T2SS), a type VI secretion system (T6SS), autotransporter, and outer membrane vesicles (OMVs). In this review, we summarize the current knowledge of secretion systems in Acinetobacter species, and highlight their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogens.
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Base de dados:
MEDLINE
Assunto principal:
Acinetobacter baumannii
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Sistemas de Secreção Tipo II
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Sistemas de Secreção Tipo V
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Sistemas de Secreção Tipo VI
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article