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Discovery of the first dual inhibitor of the 5-lipoxygenase-activating protein and soluble epoxide hydrolase using pharmacophore-based virtual screening.
Temml, Veronika; Garscha, Ulrike; Romp, Erik; Schubert, Gregor; Gerstmeier, Jana; Kutil, Zsofia; Matuszczak, Barbara; Waltenberger, Birgit; Stuppner, Hermann; Werz, Oliver; Schuster, Daniela.
Afiliação
  • Temml V; Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Garscha U; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Romp E; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
  • Schubert G; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
  • Gerstmeier J; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
  • Kutil Z; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
  • Matuszczak B; Laboratory of Plant Biotechnologies, Institute of Experimental Botany AS CR, Rozvojova 263, Prague 6 - Lysolaje, Czech Republic.
  • Waltenberger B; Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Stuppner H; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Werz O; Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.
  • Schuster D; Chair of Pharmaceutical/Medicinal Chemistry, University of Jena, Philosophenweg 14, 07743 Jena, Germany.
Sci Rep ; 7: 42751, 2017 02 20.
Article em En | MEDLINE | ID: mdl-28218273
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Epóxido Hidrolases / Proteínas Ativadoras de 5-Lipoxigenase / Anti-Inflamatórios Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Epóxido Hidrolases / Proteínas Ativadoras de 5-Lipoxigenase / Anti-Inflamatórios Idioma: En Ano de publicação: 2017 Tipo de documento: Article