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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Moniot, Sébastien; Forgione, Mariantonietta; Lucidi, Alessia; Hailu, Gebremedhin S; Nebbioso, Angela; Carafa, Vincenzo; Baratta, Francesca; Altucci, Lucia; Giacché, Nicola; Passeri, Daniela; Pellicciari, Roberto; Mai, Antonello; Steegborn, Clemens; Rotili, Dante.
Afiliação
  • Moniot S; Department of Biochemistry and Research Center for Bio-Macromolecules, University of Bayreuth , 95440 Bayreuth, Germany.
  • Forgione M; Department of Drug Chemistry and Technologies, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Lucidi A; Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia , Viale Regina Elena, 291, 00161 Rome, Italy.
  • Hailu GS; Department of Drug Chemistry and Technologies, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Nebbioso A; Department of Drug Chemistry and Technologies, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Carafa V; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. de Crecchio 7, 80138 Naples, Italy.
  • Baratta F; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. de Crecchio 7, 80138 Naples, Italy.
  • Altucci L; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. de Crecchio 7, 80138 Naples, Italy.
  • Giacché N; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples , Vico L. de Crecchio 7, 80138 Naples, Italy.
  • Passeri D; TES Pharma S.r.l. , Via P. Togliatti 20, 06073 Corciano, Perugia, Italy.
  • Pellicciari R; TES Pharma S.r.l. , Via P. Togliatti 20, 06073 Corciano, Perugia, Italy.
  • Mai A; TES Pharma S.r.l. , Via P. Togliatti 20, 06073 Corciano, Perugia, Italy.
  • Steegborn C; Department of Drug Chemistry and Technologies, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome , P. le A. Moro 5, 00185 Rome, Italy.
  • Rotili D; Department of Biochemistry and Research Center for Bio-Macromolecules, University of Bayreuth , 95440 Bayreuth, Germany.
J Med Chem ; 60(6): 2344-2360, 2017 03 23.
Article em En | MEDLINE | ID: mdl-28240897
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Sirtuína 2 / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxidiazóis / Sirtuína 2 / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article