Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1.

Ling, Sunbin; Xie, Haiyang; Yang, Fan; Shan, Qiaonan; Dai, Haojiang; Zhuo, Jianyong; Wei, Xuyong; Song, Penghong; Zhou, Lin; Xu, Xiao; Zheng, Shusen

Ling, Sunbin; Xie, Haiyang; Yang, Fan; Shan, Qiaonan; Dai, Haojiang; Zhuo, Jianyong; Wei, Xuyong; Song, Penghong; Zhou, Lin; Xu, Xiao; Zheng, Shusen.

Afiliação

Ling S; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine,, Zhejiang University, Hangzhou, China.
Xie H; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, China.
Yang F; Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang Province, China.
Shan Q; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
Dai H; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, China.
Zhuo J; Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang Province, China.
Wei X; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
Song P; Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine,, Zhejiang University, Hangzhou, China.
Zhou L; Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou, China.
Xu X; Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang Province, China.
Zheng S; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

J Hematol Oncol ; 10(1): 59, 2017 02 28.

Article em En | MEDLINE | ID: mdl-28241849

Assuntos

Arsenicais/farmacologia; Neoplasias dos Ductos Biliares/tratamento farmacológico; Colangiocarcinoma/tratamento farmacológico; Sinergismo Farmacológico; Metformina/farmacologia; Óxidos/farmacologia; Proteínas Quinases Ativadas por AMP/metabolismo; Proteínas Quinases Ativadas por AMP/fisiologia; Animais; Trióxido de Arsênio; Arsenicais/uso terapêutico; Linhagem Celular Tumoral; Xenoenxertos; Humanos; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/fisiologia; Camundongos; Camundongos Nus; Proteína Quinase 6 Ativada por Mitógeno/genética; Proteína Quinase 6 Ativada por Mitógeno/metabolismo; Proteína Quinase 6 Ativada por Mitógeno/fisiologia; Óxidos/uso terapêutico; Transdução de Sinais; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/fisiologia

Palavras-chave

Arsenic trioxide; ERK3; Intrahepatic cholangiocarcinoma; Metformin; mTORC1; p38 MAPK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxidos / Arsenicais / Neoplasias dos Ductos Biliares / Colangiocarcinoma / Sinergismo Farmacológico / Metformina Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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