Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 61(5)2017 05.
Article
em En
| MEDLINE
| ID: mdl-28242657
ABSTRACT
A novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.
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MEDLINE
Assunto principal:
Pseudomonas aeruginosa
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Piocinas
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Elementos de DNA Transponíveis
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article