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Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL).
Abal, Paula; Louzao, M Carmen; Antelo, Alvaro; Alvarez, Mercedes; Cagide, Eva; Vilariño, Natalia; Vieytes, Mercedes R; Botana, Luis M.
Afiliação
  • Abal P; Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain. paula.abal@usc.es.
  • Louzao MC; Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain. mcarmen.louzao@usc.es.
  • Antelo A; Laboratorio CIFGA S.A., Plaza Santo Domingo 20-5°, Lugo 27001, Spain. alvaro@cifga.es.
  • Alvarez M; Laboratorio CIFGA S.A., Plaza Santo Domingo 20-5°, Lugo 27001, Spain. mercedes@cifga.es.
  • Cagide E; Laboratorio CIFGA S.A., Plaza Santo Domingo 20-5°, Lugo 27001, Spain. evacagide@cifga.es.
  • Vilariño N; Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain. natalia.vilarino@usc.es.
  • Vieytes MR; Departamento de Fisiologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain. mmercedes.rodriguez@usc.es.
  • Botana LM; Departamento de Farmacologia, Facultad de Veterinaria, Universidad de Santiago de Compostela, Lugo 27002, Spain. luis.botana@usc.es.
Toxins (Basel) ; 9(3)2017 02 24.
Article em En | MEDLINE | ID: mdl-28245573
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determine for the first time the oral lethal dose 50 (LD50) and the No Observed Adverse Effect Level (NOAEL) in mice by using an accurate well-characterized TTX standard.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetrodotoxina / Poluentes Químicos da Água Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetrodotoxina / Poluentes Químicos da Água Idioma: En Ano de publicação: 2017 Tipo de documento: Article