Assembly of Dynamic P450-Mediated Metabolons-Order Versus Chaos.
Curr Mol Biol Rep
; 3(1): 37-51, 2017.
Article
em En
| MEDLINE
| ID: mdl-28255532
ABSTRACT
PURPOSE OF REVIEW We provide an overview of the current knowledge on cytochrome P450-mediated metabolism organized as metabolons and factors that facilitate their stabilization. Essential parameters will be discussed including those that are commonly disregarded using the dhurrin metabolon from Sorghum bicolor as a case study. RECENT FINDINGS:
Sessile plants control their metabolism to prioritize their resources between growth and development, or defense. This requires fine-tuned complex dynamic regulation of the metabolic networks involved. Within the recent years, numerous studies point to the formation of dynamic metabolons playing a major role in controlling the metabolic fluxes within such networks.SUMMARY:
We propose that P450s and their partners interact and associate dynamically with POR, which acts as a charging station possibly in concert with Cytb5. Solvent environment, lipid composition, and non-catalytic proteins guide metabolon formation and thereby activity, which have important implications for synthetic biology approaches aiming to produce high-value specialized metabolites in heterologous hosts.
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MEDLINE
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En
Ano de publicação:
2017
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Article