Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.

Maruoka, Masahiro; Kedashiro, Shin; Ueda, Yuki; Mizutani, Kiyohito; Takai, Yoshimi

Maruoka, Masahiro; Kedashiro, Shin; Ueda, Yuki; Mizutani, Kiyohito; Takai, Yoshimi.

Afiliação

Maruoka M; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047.
Kedashiro S; the Health Metrics Development Team, RIKEN Compass to Healthy Life Research Complex Program, 6-7-1 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, and.
Ueda Y; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047.
Mizutani K; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047.
Takai Y; From the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5-6 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, mizutani@med.kobe-u.ac.jp.

J Biol Chem ; 292(17): 6895-6909, 2017 04 28.

Article em En | MEDLINE | ID: mdl-28258213

Assuntos

Moléculas de Adesão Celular/metabolismo; Janus Quinase 2/metabolismo; Receptores da Prolactina/metabolismo; Fator de Transcrição STAT5/metabolismo; Proteína 1 Supressora da Sinalização de Citocina/metabolismo; Animais; Citoplasma/metabolismo; Feminino; Fibronectinas/metabolismo; Regulação da Expressão Gênica; Células HEK293; Humanos; Glândulas Mamárias Animais/metabolismo; Camundongos; Mutação; Fosforilação; Prolactina/metabolismo; Transdução de Sinais; Proteínas Supressoras de Tumor/metabolismo

Palavras-chave

Janus kinase (JAK); STAT transcription factor; cell adhesion; cell surface receptor; cell-cell interaction; nectin; prolactin; suppressor of cytokine signaling 1 (SOCS1)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores da Prolactina / Moléculas de Adesão Celular / Fator de Transcrição STAT5 / Janus Quinase 2 / Proteína 1 Supressora da Sinalização de Citocina Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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