Concentration-dependent linkage of dietary methionine restriction to the components of its metabolic phenotype.
Obesity (Silver Spring)
; 25(4): 730-738, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-28261952
ABSTRACT
OBJECTIVE:
Restricting dietary methionine to 0.17% produces a series of physiological responses through coordinated transcriptional effects in liver and adipose tissue. The goal of the present work was to determine the threshold concentrations above and below 0.17% at which the beneficial responses to 0.17% dietary methionine are preserved.METHODS:
Diets were formulated to restrict methionine to different degrees, followed by evaluation of the transcriptional and physiological responses to the different diets.RESULTS:
Restriction of dietary methionine to 0.25%, but not 0.34%, was partially effective in reproducing the metabolic phenotype produced by restriction of methionine to 0.17%, while restriction of methionine to 0.12% reproduced the responses produced by restriction to 0.17% but failed to support growth and caused excessive weight loss. Restriction beyond 0.12% initiated responses characteristic of essential amino acid deprivation including food aversion and rapid weight loss.CONCLUSIONS:
Restriction of dietary methionine to levels above 0.25% was without effect, while restriction to levels below 0.12% produced responses characteristic of essential amino acid deprivation. In addition, although restriction of dietary methionine to 0.12% did not evoke essential amino acid deprivation responses, it provided insufficient methionine to support growth. The ideal range of dietary methionine restriction was from 0.17% to 0.25%.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Alimentares
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Dieta
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Recomendações Nutricionais
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Metionina
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article