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Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma.
Hutchings, Kim M; Lisabeth, Erika M; Rajeswaran, Walajapet; Wilson, Michael W; Sorenson, Roderick J; Campbell, Phillip L; Ruth, Jeffrey H; Amin, Asif; Tsou, Pei-Suen; Leipprandt, Jeffrey R; Olson, Samuel R; Wen, Bo; Zhao, Ting; Sun, Duxin; Khanna, Dinesh; Fox, David A; Neubig, Richard R; Larsen, Scott D.
Afiliação
  • Hutchings KM; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Lisabeth EM; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA.
  • Rajeswaran W; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Wilson MW; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Sorenson RJ; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Campbell PL; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Ruth JH; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Amin A; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Tsou PS; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Leipprandt JR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA.
  • Olson SR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA.
  • Wen B; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Zhao T; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Sun D; UM Pharmacokinetics Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.
  • Khanna D; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Fox DA; Department of Internal Medicine, Division of Rheumatology and Clinical Autoimmunity Center of Excellence, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  • Neubig RR; Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI 48824, USA.
  • Larsen SD; Vahlteich Medicinal Chemistry Core, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: sdlarsen@med.umich.edu.
Bioorg Med Chem Lett ; 27(8): 1744-1749, 2017 04 15.
Article em En | MEDLINE | ID: mdl-28285914
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator Rho / Escleroderma Sistêmico / Pele / Ativação Transcricional / Ácidos Nipecóticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator Rho / Escleroderma Sistêmico / Pele / Ativação Transcricional / Ácidos Nipecóticos Idioma: En Ano de publicação: 2017 Tipo de documento: Article