Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS <i>In vitro</i>.

Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro.

Wobst, Heike J; Wesolowski, Steven S; Chadchankar, Jayashree; Delsing, Louise; Jacobsen, Steven; Mukherjee, Jayanta; Deeb, Tarek Z; Dunlop, John; Brandon, Nicholas J; Moss, Stephen J.

Afiliação

Wobst HJ; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, Boston MA, USA.
Wesolowski SS; IMED Biotech Unit, AstraZeneca Neuroscience IMED, AstraZeneca, Cambridge MA, USA.
Chadchankar J; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, Boston MA, USA.
Delsing L; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, BostonMA, USA; IMED Biotech Unit, AstraZeneca Discovery ScienceMölndal, Sweden.
Jacobsen S; IMED Biotech Unit, AstraZeneca Neuroscience IMED, AstraZeneca, Cambridge MA, USA.
Mukherjee J; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, Boston MA, USA.
Deeb TZ; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, Boston MA, USA.
Dunlop J; IMED Biotech Unit, AstraZeneca Neuroscience IMED, AstraZeneca, Cambridge MA, USA.
Brandon NJ; IMED Biotech Unit, AstraZeneca Neuroscience IMED, AstraZeneca, Cambridge MA, USA.
Moss SJ; AstraZeneca-Tufts Laboratory for Basic and Translational Neuroscience, Department of Neuroscience, Tufts University School of Medicine, BostonMA, USA; Department of Neuroscience, Tufts University School of Medicine, BostonMA, USA.

Front Mol Neurosci ; 10: 46, 2017.

Article em En | MEDLINE | ID: mdl-28286471

Palavras-chave

TAR DNA-binding protein 43 (TDP-43); amyotrophic lateral sclerosis (ALS); frontotemporal dementia; mutation; neurodegenerative diseases; protein misfolding disease

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2017 Tipo de documento: Article