Macrocycles as protein-protein interaction inhibitors.
Biochem J
; 474(7): 1109-1125, 2017 03 15.
Article
em En
| MEDLINE
| ID: mdl-28298556
ABSTRACT
Macrocyclic compounds such as cyclic peptides have emerged as a new and exciting class of drug candidates for inhibition of intracellular protein-protein interactions, which are challenging targets for conventional drug modalities (i.e. small molecules and proteins). Over the past decade, several complementary technologies have been developed to synthesize macrocycle libraries and screen them for binding to therapeutically relevant targets. Two different approaches have also been explored to increase the membrane permeability of cyclic peptides. In this review, we discuss these methods and their applications in the discovery of macrocyclic compounds against protein-protein interactions.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Proteínas
/
Biblioteca de Peptídeos
/
Bibliotecas de Moléculas Pequenas
/
Domínios e Motivos de Interação entre Proteínas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article