The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy.
Int J Mol Sci
; 18(3)2017 Mar 17.
Article
em En
| MEDLINE
| ID: mdl-28304339
ABSTRACT
DNA-based vaccine strategy is increasingly realized as a viable cancer treatment approach. Strategies to enhance immunogenicity utilizing tumor associated antigens have been investigated in several pre-clinical and clinical studies. The promising outcomes of these studies have suggested that DNA-based vaccines induce potent T-cell effector responses and at the same time cause only minimal side-effects to cancer patients. However, the immune evasive tumor microenvironment is still an important hindrance to a long-term vaccine success. Several options are currently under various stages of study to overcome immune inhibitory effect in tumor microenvironment. Some of these approaches include, but are not limited to, identification of neoantigens, mutanome studies, designing fusion plasmids, vaccine adjuvant modifications, and co-treatment with immune-checkpoint inhibitors. In this review, we follow a Porter's analysis analogy, otherwise commonly used in business models, to analyze various immune-forces that determine the potential success and sustainable positive outcomes following DNA vaccination using non-viral tumor associated antigens in treatment against cancer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunização
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Vacinas Anticâncer
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Vacinas de DNA
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Neoplasias
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article