Role of AHR and HIF-1α in Glioblastoma Metabolism.
Trends Endocrinol Metab
; 28(6): 428-436, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-28318896
ABSTRACT
Glioblastoma (GBM) progression is associated with metabolic remodeling in both glioma and immune cells, resulting in the use of aerobic glycolysis as the main source of energy and biosynthetic molecules. The transcription factor hypoxia-inducible factor (HIF)-1α drives this metabolic reorganization. Oxygen levels, as well as other factors, control the activity of HIF-1α. In addition, the ligand-activated transcription factor aryl hydrocarbon receptor (AHR) modulates tumor-specific immunity and can also participate in metabolic remodeling. AHR activity is regulated by tryptophan derivatives present in the tumor microenvironment. Thus, the tumor microenvironment and signaling via HIF-1α and AHR regulate the metabolism of gliomas and immune cells, modulating tumor-specific immunity and, consequently, tumor growth. Here, we review the roles of HIF-1α and AHR in cancer and immune cell metabolism in GBM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Hidrocarboneto Arílico
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Glioblastoma
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Subunidade alfa do Fator 1 Induzível por Hipóxia
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article