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Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
Tosh, Dilip K; Janowsky, Aaron; Eshleman, Amy J; Warnick, Eugene; Gao, Zhan-Guo; Chen, Zhoumou; Gizewski, Elizabeth; Auchampach, John A; Salvemini, Daniela; Jacobson, Kenneth A.
Afiliação
  • Tosh DK; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
  • Janowsky A; VA Portland Health Care System, Research Service (R&D-22), and Departments of Psychiatry and Behavioral Neuroscience, Oregon Health and Science University , Portland, Oregon 97239, United States.
  • Eshleman AJ; VA Portland Health Care System, Research Service (R&D-22), and Departments of Psychiatry and Behavioral Neuroscience, Oregon Health and Science University , Portland, Oregon 97239, United States.
  • Warnick E; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
  • Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
  • Chen Z; Department of Pharmacology and Physiology, Saint Louis University School of Medicine , St. Louis, Missouri 63104, United States.
  • Gizewski E; Department of Pharmacology, Medical College of Wisconsin , 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
  • Auchampach JA; Department of Pharmacology, Medical College of Wisconsin , 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, United States.
  • Salvemini D; Department of Pharmacology and Physiology, Saint Louis University School of Medicine , St. Louis, Missouri 63104, United States.
  • Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
J Med Chem ; 60(7): 3109-3123, 2017 04 13.
Article em En | MEDLINE | ID: mdl-28319392
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteínas da Membrana Plasmática de Transporte de Dopamina / Proteínas da Membrana Plasmática de Transporte de Norepinefrina / Agonistas do Receptor Purinérgico P1 / Nucleosídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Proteínas da Membrana Plasmática de Transporte de Dopamina / Proteínas da Membrana Plasmática de Transporte de Norepinefrina / Agonistas do Receptor Purinérgico P1 / Nucleosídeos Idioma: En Ano de publicação: 2017 Tipo de documento: Article